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However, plasma concentrations of rosuvastatin increased to a clinically significant extent about 3-fold in patients with severe renal impairment clcr 30 ml min 1.
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In cynomolgus monkeys, rosuvastatin decreases plasma cholesterol levels by 22 1 .
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in addition, healthy men were randomly divided in 3 groups to receive either placebo n 10 , rosuvastatin n 22 , or rosuvastatin combined with intravenous caffeine n 12 .